Document Detail


The pharmacokinetics and availability of niflumic acid in humans.
MedLine Citation:
PMID:  6852999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetic parameters and relative availability of niflumic acid in two different pharmaceutical preparations were studied in 12 subjects after a single oral administration. Total plasma clearance averaged 45 ml/min, and the half-life of elimination approximately 2 h, giving a distribution volume of 0.12 l/kg on the average. The values of these pharmacokinetic parameters were in agreement with the general characteristics of this type of substance, a weak acid strongly bound to plasma proteins. Comparison of the systemic availability of the two oral forms showed no difference; they were probably close to 100%.
Authors:
G Houin; D Tremblay; F Bree; A Dufour; P Ledudal; J P Tillement
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  21     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  130-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Oral
Adult
Biological Availability
Capsules
Female
Half-Life
Humans
Kinetics
Male
Nicotinic Acids / metabolism*
Niflumic Acid / administration & dosage,  blood,  metabolism*
Suspensions
Chemical
Reg. No./Substance:
0/Capsules; 0/Nicotinic Acids; 0/Suspensions; 4394-00-7/Niflumic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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