| A pharmacokinetic study of occupational and environmental benzene exposure with regard to gender. | |
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MedLine Citation:
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PMID: 9637076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using physiologically-based pharmacokinetic (PBPK) modeling, occupational, personal, and environmental benzene exposure scenarios are simulated for adult men and women. This research identifies differences in internal exposure due to physiological and biochemical gender differences. Physiological and chemical-specific model parameters were obtained from other studies reported in the literature and medical texts for the subjects of interest. Women were found to have a higher blood/air partition coefficient and maximum velocity of metabolism for benzene than men (the two most sensitive parameters affecting gender-specific differences). Additionally, women generally have a higher body fat percentage than men. These factors influence the internal exposure incurred by the subjects and should be considered when conducting a risk assessment. Results demonstrated that physicochemical gender differences result in women metabolizing 23-26% more benzene than men when subject to the same exposure scenario even though benzene blood concentration levels are generally higher in men. These results suggest that women may be at significantly higher risk for certain effects of benzene exposure. Thus, exposure standards based on data from male subjects may not be protective for the female population. |
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Authors:
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E A Brown; M L Shelley; J W Fisher |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Risk analysis : an official publication of the Society for Risk Analysis Volume: 18 ISSN: 0272-4332 ISO Abbreviation: Risk Anal. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-27 Completed Date: 1998-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109978 Medline TA: Risk Anal Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-13 Citation Subset: IM |
Affiliation:
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Air Force Institute of Technology, WPAFB, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzene / administration & dosage, pharmacokinetics*, toxicity* Environmental Exposure* Female Humans Male Maximum Allowable Concentration Models, Biological Occupational Exposure* Risk Assessment Safety Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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71-43-2/Benzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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