Document Detail


The pharmacogenetics of antiplatelet drugs.
MedLine Citation:
PMID:  17408116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Platelets play a pivotal role in coronary heart disease and atherothrombotic events, and thus antiplatelet therapy is commonly used to treat cardiovascular disease. Unfortunately, the benefits of this approach are limited, and a large proportion of treated patients will suffer a new thrombotic event, either within the first few weeks following stent implantation or in the follow-up period after myocardial infarction. This lack of clinical benefit may be related to a heterogeneous response to antiplatelet drugs among individuals. Recently, the field of pharmacogenetics has tried to identify gene variants in order to explain tile observed heterogeneity in patient responses to drugs. This review explores the genetic influences on antiplatelet drug efficacy by analyzing the modulating role of different genetic polymorphisms on individual responses to antiplatelet therapy.
Authors:
Francisco Marín; Vanessa Roldán; Rocío González-Conejero; Javier Corral
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  8     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-05     Completed Date:  2007-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
Affiliation:
Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Madrid-Cartagen s/n El Palmar, Murcia, 30008 Spain. fcomarino@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Humans
Myocardial Infarction / genetics,  prevention & control*
Pharmacogenetics / methods*,  trends
Platelet Aggregation Inhibitors / chemistry,  classification,  therapeutic use*
Polymorphism, Genetic
Treatment Outcome
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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