Document Detail

The pharmacoeconomics of peri-operative beta-blocker therapy.
MedLine Citation:
PMID:  16409334     Owner:  NLM     Status:  MEDLINE    
It is widely recommended that beta-blockade be used peri-operatively as it may reduce the incidence of postoperative cardiovascular complications including death. However, there are few data concerning the cost-effectiveness of such strategies. We have analysed the pharmacoeconomics of acute beta-blockade using data from eight prospective peri-operative studies in which patients underwent elective non-cardiac surgery, and in which the incidence of adverse side-effects of treatment, as well as clinical outcomes, have been reported. The costs of treatment were based on the NHS reference costs for 2004. From these data, the number-needed-to-treat (NNT) to prevent a major cardiovascular complication (including cardiovascular death) in high-risk patients was 18.5. This is comparable to the NNT for peri-operative statin therapy. The incremental cost of peri-operative beta-blockade (costs of drug acquisition and of treating associated adverse drug events) was 67.80 pounds sterling per patient. This results in a total cost of 1254.30 pounds sterling per peri-operative cardiovascular complication prevented. However, there is evidence that in patients at lower cardiovascular risk, beta-blockers may be potentially harmful, since their adverse effects (hypotension, bradycardia) may outweigh their potential cardioprotective effects.
B M Biccard; J W Sear; P Foëx
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  61     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-13     Completed Date:  2006-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  4-8     Citation Subset:  AIM; IM    
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects,  economics*,  therapeutic use
Cardiovascular Diseases / economics,  prevention & control
Cost-Benefit Analysis
Drug Costs / statistics & numerical data
Great Britain
Health Care Costs / statistics & numerical data
Perioperative Care / economics*,  methods
Postoperative Complications / economics,  prevention & control
Prospective Studies
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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