| The pharmacoeconomics of peri-operative beta-blocker therapy. | |
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MedLine Citation:
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PMID: 16409334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is widely recommended that beta-blockade be used peri-operatively as it may reduce the incidence of postoperative cardiovascular complications including death. However, there are few data concerning the cost-effectiveness of such strategies. We have analysed the pharmacoeconomics of acute beta-blockade using data from eight prospective peri-operative studies in which patients underwent elective non-cardiac surgery, and in which the incidence of adverse side-effects of treatment, as well as clinical outcomes, have been reported. The costs of treatment were based on the NHS reference costs for 2004. From these data, the number-needed-to-treat (NNT) to prevent a major cardiovascular complication (including cardiovascular death) in high-risk patients was 18.5. This is comparable to the NNT for peri-operative statin therapy. The incremental cost of peri-operative beta-blockade (costs of drug acquisition and of treating associated adverse drug events) was 67.80 pounds sterling per patient. This results in a total cost of 1254.30 pounds sterling per peri-operative cardiovascular complication prevented. However, there is evidence that in patients at lower cardiovascular risk, beta-blockers may be potentially harmful, since their adverse effects (hypotension, bradycardia) may outweigh their potential cardioprotective effects. |
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Authors:
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B M Biccard; J W Sear; P Foëx |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anaesthesia Volume: 61 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-13 Completed Date: 2006-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 4-8 Citation Subset: AIM; IM |
Affiliation:
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Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. bruce.biccard@nda.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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adverse effects,
economics*,
therapeutic use Cardiovascular Diseases / economics, prevention & control Cost-Benefit Analysis Drug Costs / statistics & numerical data Great Britain Health Care Costs / statistics & numerical data Humans Perioperative Care / economics*, methods Postoperative Complications / economics, prevention & control Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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