Document Detail


The phagocyte oxidative metabolism function in ankylosing spondylitis.
MedLine Citation:
PMID:  1664542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phagocyte oxydative metabolism function was measured using chemiluminescence in microamounts of whole blood in 15 ankylosing spondylitis (AS) patients (10 were B27 positive), and in 17 controls. It was obtained from cells at rest, and following stimulation (latex, zymosan, fMLP), with luminol and lucigenin as amplifiers. The maximal light intensity was significantly higher (P less than 0.01) in AS compared to the controls in resting cells as well as in those after stimulation. There was no difference between HLA-B27 positive or negative AS patients. The increase in oxidative metabolism of the phagocyte system in AS was more evident in the luminol dependent assay, suggesting an activation of the myeloperoxydase system.
Authors:
D Wendling; J M Didier; D A Vuitton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rheumatology international     Volume:  11     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  187-9     Citation Subset:  IM    
Affiliation:
Service de Rhumatologie, Centre Hospitalier Régional et Universitaire, Besançon, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Humans
Latex / pharmacology
Luminescent Measurements
Middle Aged
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Oxidation-Reduction
Peroxidase / analysis,  metabolism
Phagocytes / drug effects,  metabolism*,  physiology*
Spondylitis, Ankylosing / blood,  metabolism*,  physiopathology*
Zymosan / pharmacology
Chemical
Reg. No./Substance:
0/Latex; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 9010-72-4/Zymosan; EC 1.11.1.7/Peroxidase

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