Document Detail


pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans.
MedLine Citation:
PMID:  9649499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To build complex organs, embryos have evolved mechanisms that integrate the development of cells unrelated to one another by cell type or ancestry. Here we show that the pha-4 locus establishes organ identity for the Caenorhabditis elegans pharynx. In pha-4 mutants, pharyngeal cells are transformed into ectoderm. Conversely, ectopic pha-4 expression produces excess pharyngeal cells. pha-4 encodes an HNF-3 homolog selectively expressed in the nascent digestive tract, including all pharynx precursors at the time they are restricted to a pharyngeal fate. We suggest that pha-4 is a key component of a transcription-based mechanism to endow cells with pharyngeal organ identity.
Authors:
M A Horner; S Quintin; M E Domeier; J Kimble; M Labouesse; S E Mango
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes & development     Volume:  12     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-29     Completed Date:  1998-07-29     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1947-52     Citation Subset:  IM    
Affiliation:
Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / embryology*,  genetics*
DNA-Binding Proteins*
Digestive System / embryology
Forkhead Transcription Factors
Gene Expression Regulation, Developmental / physiology
Genes, Helminth* / physiology
Nuclear Proteins / genetics
Pharynx / embryology*
Sequence Homology, Amino Acid
Trans-Activators / genetics*
Transcription Factors / genetics
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/FOXI1 protein, human; 0/FOXJ1 protein, human; 0/Forkhead Transcription Factors; 0/Nuclear Proteins; 0/Trans-Activators; 0/Transcription Factors
Comments/Corrections

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