| A personal history of markers of myocyte injury [myocardial infarction]. | |
| | |
MedLine Citation:
|
PMID: 17451663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The measurement of proteins in blood to reflect damage to the heart is one of the most successful examples of easily measured biomarkers identifying a serious major health problem. The concept of using a blood test to reflect organ or cell injury requires a substance that is very abundant in the target cell, has a means of reaching blood, a reasonable half-life in blood, and ideally a specific form reflective only of the target cell in tissue. The myocyte's major role is contraction so proteins involved in contraction or the energy to support it should be good candidate markers. CONCLUSIONS: All the various biomarkers that have been used to detect cardiac damage are involved in contraction or energy metabolism, but the markers evolved empirically starting with transaminases in the 1950s leading to troponins in the 1990s. This history is reviewed with reflections on my experiences with developing assays for CK-MB and Troponin I. |
| | |
Authors:
|
Jack H Ladenson |
Related Documents
:
|
5789813 - Liberation of a bradykinin-like substance in the circulating blood of dogs by trypsin, ... 2723633 - Determination of brain interstitial concentrations by microdialysis. 18791143 - Technical note: comparison between two tracing methods with ultrasonography to determin... |
Publication Detail:
|
Type: Historical Article; Journal Article; Review Date: 2007-02-28 |
Journal Detail:
|
Title: Clinica chimica acta; international journal of clinical chemistry Volume: 381 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-05-15 Completed Date: 2007-07-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
|
Washington University, School of Medicine, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, St. Louis, MO, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers* Creatine Kinase / analysis Hematologic Tests History, 20th Century Humans Myocardial Infarction / enzymology*, history, pathology Myocytes, Cardiac / enzymology*, pathology Myoglobin / analysis Troponin / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Myoglobin; 0/Troponin; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparative study of the effects of dimethylsulfoxide and glycerol on the bicontinuous cubic struc...
Next Document: Induction of antiphospholipid antibodies and antiphospholipid syndrome-like autoimmunity in naive mi...