Document Detail

The persistent problem of new-onset postoperative atrial fibrillation: a single-institution experience over two decades.
MedLine Citation:
PMID:  20434173     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Postoperative atrial fibrillation is the most common complication after cardiac surgery. A variety of postoperative atrial fibrillation risk factors have been reported, but study results have been inconsistent or contradictory, particularly in patients with preexisting atrial fibrillation. The incidence of postoperative atrial fibrillation was evaluated in a group of 10,390 patients undergoing cardiac surgery among a comprehensive range of risk factors to identify reliable predictors of postoperative atrial fibrillation.
METHODS: This 20-year retrospective study examined the relationship between postoperative atrial fibrillation and demographic factors, preoperative health conditions and medications, operative procedures, and postoperative complications. Multivariate logistic regression models were used to evaluate potential predictors of postoperative atrial fibrillation.
RESULTS: Increasing age, mitral valve surgery (odds ratio=1.91), left ventricular aneurysm repair (odds ratio=1.57), aortic valve surgery (odds ratio=1.52), race (Caucasian) (odds ratio=1.51), use of cardioplegia (odds ratio=1.36), use of an intraaortic balloon pump (odds ratio=1.28), previous congestive heart failure (odds ratio=1.28), and hypertension (odds ratio=1.15) were significantly associated with postoperative atrial fibrillation. The non-linear relationship between age and postoperative atrial fibrillation revealed the acceleration of postoperative atrial fibrillation risk in patients aged 55 years or more. In patients undergoing coronary artery bypass grafting, increasing age and previous congestive heart failure were the only factors associated with a higher risk of postoperative atrial fibrillation. There was no trend in incidence of postoperative atrial fibrillation over time. No protective factors against postoperative atrial fibrillation were detected, including commonly prescribed categories of medications.
CONCLUSIONS: The persistence of the problem of postoperative atrial fibrillation and the modest predictability using common risk factors suggest that limited progress has been made in understanding its cause and treatment.
Jeanne Shen; Shelly Lall; Victoria Zheng; Patricia Buckley; Ralph J Damiano; Richard B Schuessler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  141     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-18     Completed Date:  2011-02-17     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-70     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / epidemiology,  etiology*,  prevention & control
Cardiac Surgical Procedures / adverse effects*
Chi-Square Distribution
Logistic Models
Middle Aged
Odds Ratio
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Young Adult
Grant Support
2T35HL007815-11A1/HL/NHLBI NIH HHS; R01 HL 032257/HL/NHLBI NIH HHS; R01 HL085113/HL/NHLBI NIH HHS; R01 HL085113/HL/NHLBI NIH HHS; R01 HL085113-01A1/HL/NHLBI NIH HHS; R01 HL085113-02/HL/NHLBI NIH HHS; R01 HL085113-03/HL/NHLBI NIH HHS; T32 HL007776/HL/NHLBI NIH HHS

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