| The persistence of hibernating myocardium after acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 9519319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To establish the persistence of hibernating myocardium initially detected after myocardial infarction treated with thrombolysis. METHODS AND RESULTS: Fourteen patients underwent gated positron emission tomography with 18-fluoro-deoxyglucose and N13-ammonia at a median of 8 days after first myocardial infarction. Repeat scans were performed at a median of 13 weeks post-infarction. A total of 148 (30.9%) myocardial segments showed reduced N13-ammonia uptake at the time of the first scan compared with 154.5 (32.2%) segments at the time of repeat imaging. The median change in the number of segments with reduced perfusion was -1.0. Initially 13 subjects had hibernating myocardium, seven patients had large areas and six had smaller regions. Six (46.2%) subjects had repeat scans showing unchanged areas of hibernating tissue and seven had second scans demonstrating changes in the size of the region of hibernating myocardium. One patient had no hibernating myocardium on either scan. CONCLUSIONS: Positron emission tomography performed several months after myocardial infarction demonstrates significant changes in myocardial perfusion. However, a reduction in the number of segments with reduced perfusion does not always result in an improvement in myocardial metabolism and contraction. Whilst most regions of hibernating myocardium were still present several months after infarction, in only approximately half was the size of the mismatched region unchanged. Therefore it is not possible to predict the fate of hibernating myocardium which is present after infarction. |
| | |
Authors:
|
J N Adams; R J Trent; M Norton; P Mikecz; S Walton; N Evans |
Related Documents
:
|
9617639 - Fluorodeoxyglucose uptake in dysfunctional myocardium subtended by an occluded coronary... 15118289 - Usefulness of stress myocardial perfusion imaging for evaluating asymptomatic patients ... 8472709 - Derivation and validation of a new angiographic score of right coronary artery perfusion. 11593219 - Usefulness of distinct activity thresholds according to baseline regional asynergy for ... 2130569 - Assessment of myocardial perfusion and viability with technetium-99m methoxyisobutyl is... 8553409 - Single-photon emission computed tomography using hexamethylpropyleneamine oxime in the ... 9277549 - Enhanced responsiveness of cardiac vagal chemosensitive endings to bradykinin in heart ... 2960499 - Left atrial abnormalities indicating diastolic ventricular dysfunction in cardiopathy o... 2444359 - Neurogenic regulation of coronary blood flow: evidence for a central nervous system pat... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European heart journal Volume: 19 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1998 Feb |
Date Detail:
|
Created Date: 1998-04-30 Completed Date: 1998-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 255-62 Citation Subset: IM |
Affiliation:
|
Cardiac Department, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Ammonia / diagnostic use Coronary Circulation Fluorodeoxyglucose F18 / diagnostic use Humans Male Middle Aged Myocardial Contraction / physiology Myocardial Infarction / complications*, physiopathology, radionuclide imaging Myocardial Stunning / etiology*, physiopathology*, radionuclide imaging Nitrogen Radioisotopes / diagnostic use Radiopharmaceuticals / diagnostic use Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
|
0/Nitrogen Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low dose imipramine improves chest pain but not quality of life in patients with angina and normal c...
Next Document: Acute and one year follow-up results after vessel size adapted PTCA using intracoronary ultrasound.