| Is periventricular leucomalacia a result of hypoxic-ischaemic injury? Hypocapnia and the preterm brain. | |
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MedLine Citation:
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PMID: 11275650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Decrease in the arterial partial pressure of carbon dioxide (PaCO(2)) causes a reduction in cerebral blood flow in humans and in most animal species; in adults as well as in newborns and even in fetal life. Severely decreased PaCO(2) increases cerebral lactate production, modifies spontaneous electric brain activity, and may decrease the metabolic rate of oxygen. A relation between very low PaCO(2) and brain injury, however, has not been shown in adult humans or full-term newborn infants, nor in perinatal animals. In contrast, an association between low PaCO(2) and cerebral palsy and white matter injury in preterm infants has been reported repeatedly. A cause-and-effect relation is suggested by data from the immature rat: brain damage induced by ligation of a carotid artery can be reduced by adding CO(2) to the inspired gas and hence avoiding the consequences of spontaneous hyperventilation. This may be relevant for the clinical care of preterm infants, since PaCO(2) to a large extent is a function of respiratory management. The questions to be addressed are whether hypocapnia sensitizes the brain to hypoxaemia, and also whether the escape mechanisms are less effective in the preterm human brain. |
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Authors:
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G Greisen; R C Vannucci |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biology of the neonate Volume: 79 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2001 |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-07-12 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 194-200 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Department of Neonatology, Rigshospitalet, Copenhagen, Denmark. greisen@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / blood supply, metabolism Brain Diseases / etiology Carbon Dioxide / blood Humans Hyperventilation / complications Hypoxia-Ischemia, Brain / complications* Infant, Newborn Infant, Premature* Leukomalacia, Periventricular / etiology* Oxygen / blood |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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