| A peripheral mechanism for behavioral adaptation to specific "bitter" taste stimuli in an insect. | |
| | |
MedLine Citation:
|
PMID: 11331398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animals have evolved several chemosensory systems for detecting potentially dangerous foods in the environment. Activation of specific sensory cells within these chemosensory systems usually elicits an aversive behavioral response, leading to avoidance of the noxious foods. Although this aversive behavioral response can be adaptive, there are many instances in which it generates "false alarms," causing animals to reject harmless foods. To minimize the number of false alarms, animals have evolved a variety of physiological mechanisms for selectively adapting their aversive behavioral response to harmless noxious compounds. We examined the mechanisms underlying exposure-induced adaptation to specific "bitter" compounds in Manduca sexta caterpillars. M. sexta exhibits an aversive behavioral response to many plant-derived compounds that taste bitter to humans, including caffeine and aristolochic acid. This aversive behavioral response is mediated by three pairs of bitter-sensitive taste cells: one responds vigorously to aristolochic acid alone, and the other two respond vigorously to both caffeine and aristolochic acid. We found that 24 hr of exposure to a caffeinated diet desensitized all of the caffeine-responsive taste cells to caffeine but not to aristolochic acid. In addition, we found that dietary exposure to caffeine adapted the aversive behavioral response of the caterpillar to caffeine, but not to aristolochic acid. We propose that the adapted aversive response to caffeine was mediated directly by the desensitized taste cells and that the adapted aversive response did not generalize to aristolochic acid because the signaling pathway for this compound was insulated from that for caffeine. |
| | |
Authors:
|
J I Glendinning; H Brown; M Capoor; A Davis; A Gbedemah; E Long |
Related Documents
:
|
6364978 - On the presence, structure and probable functional role of taste buds located on the la... 19012068 - Genetic variation in bitter taste and plasma markers of anti-oxidant status in college ... 15735638 - Food preferences of captive gray short-tailed opossums (monodelphis domestica). 8700948 - Carbohydrate- and protein-conditioned flavor preferences: effects of nutrient preloads. 22369738 - Milking parlour size, pre-milking routine and stage of lactation affect efficiency of m... 15384318 - Effects of dietary fat and carbohydrate on appetite vary depending upon site and struct... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 21 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2001 May |
Date Detail:
|
Created Date: 2001-05-24 Completed Date: 2001-06-21 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 3688-96 Citation Subset: IM |
Affiliation:
|
Department of Biological Science, Barnard College, Columbia University, New York, New York 10027, USA. jglendinning@barnard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects,
physiology* Animals Aristolochic Acids* Caffeine / pharmacology Chemoreceptor Cells / drug effects, physiology Drug Tolerance / physiology Feeding Behavior / drug effects, physiology* Food, Formulated Larva Manduca Phenanthrenes / pharmacology Stimulation, Chemical Taste / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
5 R29 DC 02416/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Aristolochic Acids; 0/Phenanthrenes; 313-67-7/aristolochic acid I; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Susceptibility to kindling and neuronal connections of the anterior claustrum.
Next Document: Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the bas...