Document Detail

A perinatal pathology view of preterm labor.
MedLine Citation:
PMID:  11320349     Owner:  NLM     Status:  MEDLINE    
The development and widespread use of tocolytic agents over the past 2 decades has not appeared to substantially affect the overall incidence of preterm delivery in the United States. Preterm delivery, therefore, remains one of the most poorly controlled and poorly understood mechanisms of perinatal morbidity and mortality and a significant strain on public health resources. The purpose of this review is to examine what is currently understood about the clinical manifestations and indicators of preterm delivery, and what, if any, may be the contribution of placental pathology to the understanding of the structural and functional abnormalities that may precede these clinical signs. Two case studies will be used to show how placental pathology may document a pattern of reproductive failure that eludes current methods of clinical screening. A retrospective analysis of what may have gone wrong in the pregnancies, focusing on the placental lesions, may contribute to a greater understanding of the heterogeneous overall processes behind recurrent idiopathic preterm delivery. Such analysis, in conjunction with known clinical factors, may guide the development of better-directed diagnostics and therapies.
K A Starzyk; C M Salafia
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Medscape women's health     Volume:  5     ISSN:  1521-2076     ISO Abbreviation:  Medscape Womens Health     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-04-26     Completed Date:  2002-01-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  100844142     Medline TA:  Medscape Womens Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1     Citation Subset:  K    
New England Clinical Communications, Marlborough, Massachusetts, USA.
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MeSH Terms
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature / etiology*,  pathology
Placenta / blood supply,  pathology*
Pregnancy Complications, Hematologic / pathology*
Pregnancy Complications, Infectious / pathology*
Risk Factors
Streptococcal Infections / pathology
Streptococcus agalactiae / isolation & purification
Thrombophilia / pathology
Umbilical Cord / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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