Document Detail

The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates.
MedLine Citation:
PMID:  19166120     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Neonates with a single umbilical artery (SUA) are considered at increased risk for chromosomal and structural abnormalities, and an increased adverse perinatal outcome. OBJECTIVE: The specific aims of our study were to evaluate (1) the association of asymptomatic infants with isolated SUA and perinatal outcomes and (2) whether asymptomatic neonates with isolated SUA at birth need full investigation. METHODS: The inclusion criteria for the study were full-term neonates with isolated SUA delivered from January 1996 to December 2006. For a control group, we used the next consecutive two newborns delivered after the SUA case in the same maternity ward with matched gestational age and without phenotypic features suspicious for aneuploidy delivered after each SUA group subject. All prenatal, peripartum and delivery records were reviewed for maternal demographics, associated anomalies, karyotypic analysis, pregnancy complications and perinatal outcomes. All SUA cases had undergone sonogram for renal anomalies. RESULTS: We enrolled 14 and 28 cases into the SUA and control groups respectively. There was all normal karyotyping for the 14 cases. The placental weight in SUA was significantly Lighter compared to that in the control group (597.1+/-175.4 vs. 709.3+/-95.2 g, p=0.010). All renal sonographic screens and karyotyping in the SUA group were normal. The incidence of small for gestational age (SGA) in SUA group was higher compared to control group (SGA, 5/14, 35.7% vs. 1/28, 3.6%, p=0.011) and less body length (48.7+/-5.0 vs. 50.8+/-1.8 cm, p=0.028). CONCLUSION: SUA is a relatively rare finding. When a SUA is identified, the routine check of karyotyping and kidney sonography for possible chromosome and associated renal anomalies may be unnecessary. According to lighter placental weight probably causing the higher incidence of small for gestational age (SGA), pregnancies with isolated SUA should be carefully monitored for evidence of fetal growth restriction.
Shu-Chi Mu; Cheng-Hui Lin; Yi-Ling Chen; Tseng-Chen Sung; Chyi-Huey Bai; Guey-Mei Jow
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  49     ISSN:  1875-9572     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-10     Revised Date:  2009-03-31    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Department of Pediatrics, Shin-Kong Wu Ho-Su Memorial Hospital.
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MeSH Terms
Infant, Newborn
Kidney / ultrasonography
Organ Size
Placenta / anatomy & histology
Umbilical Arteries / abnormalities*
Erratum In:
Pediatr Neonatol. 2009 Feb;50(1):39

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