Document Detail

The perinatal impact of cocaine, amphetamine, and opiate use detected by universal intrapartum screening.
MedLine Citation:
PMID:  2240103     Owner:  NLM     Status:  MEDLINE    
Universal urine testing for cocaine, amphetamines, and opiates was performed on 1643 women admitted to an obstetric service for a 1-year period with 20.5% having positive results. There were 299 patients with positive toxicology results matched for race and discharge date with patients having negative toxicology and drug history. Significant differences in age, prior obstetric history, prenatal care, alcohol history, and smoking were noted between groups. There was a significant decrease in birth weight, head circumference, length, and gestational age for the drug-positive group, which was most marked in cocaine and multiple drug users. These differences persisted after we controlled for smoking, prenatal care, and prior preterm births. Differences in birth weight and head circumference remained after we controlled for gestational age. Rates of congenital anomalies and abruptio placental were similar between groups. Perinatal substance abuse is independently associated with growth retardation and prematurity. Multiple risk factors are frequently present, necessitating a comprehensive approach to prenatal care.
K M Gillogley; A T Evans; R L Hansen; S J Samuels; K K Batra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  163     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-14     Completed Date:  1990-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1535-42     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of California, Davis.
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MeSH Terms
Analysis of Variance
Birth Weight / drug effects
Body Height / drug effects
Chi-Square Distribution
Gestational Age
Infant, Newborn
Labor, Obstetric
Pregnancy Complications* / diagnosis
Pregnancy Outcome*
Prenatal Care
Regression Analysis
Substance Abuse Detection
Substance-Related Disorders / complications*,  diagnosis
Reg. No./Substance:
0/Narcotics; 300-62-9/Amphetamine; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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