Document Detail

The perils of ignoring design effects in experimental studies: lessons from a mammography screening trial.
MedLine Citation:
PMID:  23289517     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Threats to external validity, including pretest sensitisation and the interaction of selection and an intervention, are frequently overlooked by researchers despite their potential to significantly influence study outcomes. The purpose of this investigation was to conduct secondary data analyses to assess the presence of external validity threats in the setting of a randomised trial designed to promote mammography use in a high-risk sample of women.
DESIGN: During the trial, recruitment and intervention, implementation took place in three cohorts (with different ethnic composition), utilising two different designs (pretest-posttest control group design and posttest only control group design).
RESULTS: Results reveal that the intervention produced different outcomes across cohorts, dependent upon the research design used and the characteristics of the sample.
CONCLUSION: These results illustrate the importance of weighing the pros and cons of potential research designs before making a selection and attending more closely to issues of external validity.
Beth A Glenn; Roshan Bastani; Annette E Maxwell
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Publication Detail:
Type:  Journal Article     Date:  2013-01-07
Journal Detail:
Title:  Psychology & health     Volume:  28     ISSN:  1476-8321     ISO Abbreviation:  Psychol Health     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-17     Completed Date:  2013-06-07     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  8807983     Medline TA:  Psychol Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  593-602     Citation Subset:  IM    
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MeSH Terms
Breast Neoplasms / prevention & control
Cohort Studies
Early Detection of Cancer / utilization*
Mammography / utilization*
Middle Aged
Randomized Controlled Trials as Topic / methods*
Reproducibility of Results
Research Design / standards*
Risk Assessment
Grant Support
P30 CA016042/CA/NCI NIH HHS; R29 CA051142/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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