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The perihematomal glutamate level is associated with the outcome of patients with basal ganglia hematomas treated by minimally invasive procedures.
MedLine Citation:
PMID:  23676149     Owner:  NLM     Status:  Publisher    
INTRODUCTION: The purpose of this study was to provide pathophysiological evidences for the time window of minimally invasive (MI) procedures for evacuating intracerebral hematoma by observing the perihematomal glutamate level and its correlation with the outcome of the patients treated with MI surgery. METHODS: One hundred consecutive patients with intracerebral hemorrhage (ICH) in the basal ganglia were assigned to either a medical treatment group (MT group, 20 patients) or a minimally invasive treatment group (MI group, 80 patients). The intracerebral hematoma was evacuated using stereotactic MI surgery within 6 hours, 12 hours, 18 hours, or 24 hours of symptom onset based on the interval between the initial hemorrhage to the patients? arrival at the hospital. Perihematomal glutamate levels and brain water content were measured in 10 randomly selected patients in each MI subgroup. The outcome of the patients was determined by the National Institute of Health Stroke Scale (NIHSS) and Modified Ranking Scale (MRS) within 6 months after admission. RESULTS: The perihematomal glutamate levels and brain water content increased gradually as the intervals from symptom onset to surgery were prolonged. Minimally invasive surgery at all the investigated time points could improve the neurological functions. Performing the MI procedures in 6 hours showed the most remarkable decrease of NIHSS and MRS, and secondarily in 12 hours. CONCLUSIONS: Minimally invasive surgery could be effective in the treatment of patients with ICH. The optimal time window for MI surgery may be within 6-12 hours of symptom onset.
Guofeng Wu; Shen Li; Likun Wang; Yuanhong Mao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-14
Journal Detail:
Title:  Neurological research     Volume:  -     ISSN:  1743-1328     ISO Abbreviation:  Neurol. Res.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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