Document Detail


The periaqueductal grey area and control of blood pressure in neurodegeneration.
MedLine Citation:
PMID:  23812562     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The periaqueductal/periventricular grey area (PAG/PVG) is a midbrain nucleus with an important role in pain signalling and autonomic control. We present the case of an initially hypertensive man who developed a presumed neurodegenerative disorder over a decade, characterised by progressive right-sided chronic pain, extra-pyramidal symptoms and autonomic dysfunction including postural hypotension, sleep apnoea, and bladder instability. He underwent a variety of treatments for his symptoms, including deep brain stimulation (DBS) of the PAG/PVG. 24-h blood pressure monitoring was carried out 1 and 5 years after implantation. Although the DBS initially produced a significant reduction in blood pressure, the effect was significantly reversed when the same tests were repeated 5 years after surgery. This may imply a functional involvement of the PAG/PVG in the neurodegenerative process.
Authors:
Holly Sitsapesan; Alexander L Green; Tipu Z Aziz; Erlick A C Pereira
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-30
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  -     ISSN:  1619-1560     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-7-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Nuffield Department of Surgical Science, University of Oxford, Level 3, West Wing, Oxford, OX3 9DU, UK, hollysitsapesan@gmail.com.
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