Document Detail


The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting.
MedLine Citation:
PMID:  21903137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies using morphine-treated dams reported a role for the rostral lateral periaqueductal gray (rlPAG) in the behavioral switching between nursing and insect hunting, likely to depend on an enhanced seeking response to the presence of an appetitive rewarding cue (i.e., the roach). To elucidate the neural mechanisms mediating such responses, in the present study, we first observed how the rlPAG influences predatory hunting in male rats. Our behavioral observations indicated that bilateral rlPAG NMDA lesions dramatically interfere with prey hunting, leaving the animal without chasing or attacking the prey, but do not seem to affect the general levels of arousal, locomotor activity and regular feeding. Next, using Phaseolus vulgaris-leucoagglutinin (PHA-L), we have reviewed the rlPAG connection pattern, and pointed out a particularly dense projection to the hypothalamic orexinergic cell group. Double labeled PHA-L and orexin sections showed an extensive overlap between PHA-L labeled fibers and orexin cells, revealing that both the medial/perifornical and lateral hypothalamic orexinergic cell groups receive a substantial innervation from the rlPAG. We have further observed that both the medial/perifornical and lateral hypothalamic orexinergic cell groups up-regulate Fos expression during prey hunting, and that rlPAG lesions blunted this Fos increase only in the lateral hypothalamic, but not in the medial/perifornical, orexinergic group, a finding supposedly associated with the lack of motivational drive to actively pursue the prey. Overall, the present results suggest that the rlPAG should exert a critical influence on reward seeking by activating the lateral hypothalamic orexinergic cell group.
Authors:
Sandra Regina Mota-Ortiz; Marcia Harumi Sukikara; Jackson Cioni Bittencourt; Marcus Vinícius Baldo; Carol Fuzeti Elias; Luciano Freitas Felicio; Newton Sabino Canteras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-30
Journal Detail:
Title:  Behavioural brain research     Volume:  226     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-10-19     Completed Date:  2012-02-09     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arousal / drug effects,  physiology
Excitatory Amino Acid Agonists / pharmacology
Hypothalamic Area, Lateral / drug effects,  metabolism
Intracellular Signaling Peptides and Proteins / metabolism
Male
Motor Activity / physiology
N-Methylaspartate / pharmacology
Neurons / drug effects,  metabolism
Neuropeptides / metabolism
Periaqueductal Gray / drug effects,  metabolism*
Predatory Behavior / drug effects,  physiology*
Rats
Rats, Wistar
Reward*
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Agonists; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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