Document Detail


The percutaneous assessment of regional and acute coronary hot unstable plaques by thermographic evaluation (PARACHUTE) study: a prospective reproducibility and prognostic clinical study using thermography to predict future ischemic cardiac events.
MedLine Citation:
PMID:  15385205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravascular thermography is currently being considered as a valuable tool in assessing macrophage-rich plaques. Since it is unknown what the prognostic value is of non-obstructive atherosclerotic plaques showing temperature heterogeneity, we designed the PARACHUTE study, a prospective, reproducibility, and prognostic clinical study using thermography in patients presenting with an unstable coronary syndrome. The primary endpoint of the study is the predictive value of temperature heterogeneity towards the occurrence of ischemic coronary events and hospitalization for ischemia and/or angina. The secondary endpoints are the predictive value of high-risk plaques associated with the development of future cardiac events, assessment of safety of the procedure, assessment of temperature reproducibility and heterogeneity in coronary arteries, as defined by the total thermal burden towards the occurrence of any cardiac event. Based on an event rate of death and myocardial infarction at 1 year of 10%, a sample size of 260 patients with presumed coronary artery disease, and positive troponin level who are scheduled to undergo an intervention will be included. All three main epicardiac vessels will undergo angiography and thermography at baseline after revascularization of the flow-limiting vessel. At 12 months, angiography of all vessels and thermography of the vessel with the highest thermographic burden will be performed. Independent core laboratories will assess outcomes and a clinical endpoint committee will assess clinical events.
Authors:
Stefan Verheye; Glenn Van Langenhove; Gerrit-Anne van Es; Patrick Serruys
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  International journal of cardiovascular interventions     Volume:  6     ISSN:  1462-8848     ISO Abbreviation:  Int J Cardiovasc Intervent     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-23     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815622     Medline TA:  Int J Cardiovasc Intervent     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Affiliation:
Department of Interventional Cardiology, Middelheim Hospital, Antwerp, Belgium. stefan.verheye@pandora.be
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Angina, Unstable / diagnosis
Coronary Angiography
Coronary Disease / diagnosis*
Follow-Up Studies
Forecasting
Humans
Myocardial Infarction / diagnosis
Myocardial Ischemia / diagnosis
Predictive Value of Tests
Prognosis
Prospective Studies
ROC Curve
Reproducibility of Results
Thermography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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