Document Detail


The percutaneous absorption of salicylic acid.
MedLine Citation:
PMID:  15633967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present paper reports on the penetration of salicylic acid, a substance with high permeability, through swine skin. Liquid scintillation counter and autoradiographic measurements were performed, on the excised swine skin to which ointment had been applied. The results indicated that the substance penetrated mainly through transfollicular route and was deposited transiently at various levels of each follicle, resulting in zig-zag pattern on the liquid scintillation counter curve. The autoradiographic study also revealed a heavy transfollicular pattern of the substance though a slight transepidermal pattern was also noted. Whether the substance penetrates because of its lipid solubility or because of its affinity to the keratinous tissue is still open to question.
Authors:
H Takahashi; T Ishii; K Tanabe; H Ikeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  3     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  2005-01-06     Completed Date:  2005-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, School of Medicine, Teikyo University, Kaga-2, Itabashi-ku, Tokyo 173, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Female
Salicylic Acid / pharmacokinetics*
Skin Absorption*
Swine
Chemical
Reg. No./Substance:
69-72-7/Salicylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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