| The percutaneous absorption of salicylic acid. | |
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MedLine Citation:
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PMID: 15633967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present paper reports on the penetration of salicylic acid, a substance with high permeability, through swine skin. Liquid scintillation counter and autoradiographic measurements were performed, on the excised swine skin to which ointment had been applied. The results indicated that the substance penetrated mainly through transfollicular route and was deposited transiently at various levels of each follicle, resulting in zig-zag pattern on the liquid scintillation counter curve. The autoradiographic study also revealed a heavy transfollicular pattern of the substance though a slight transepidermal pattern was also noted. Whether the substance penetrates because of its lipid solubility or because of its affinity to the keratinous tissue is still open to question. |
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Authors:
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H Takahashi; T Ishii; K Tanabe; H Ikeda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 3 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 1976 Aug |
Date Detail:
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Created Date: 2005-01-06 Completed Date: 2005-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: Japan |
Other Details:
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Languages: eng Pagination: 135-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, School of Medicine, Teikyo University, Kaga-2, Itabashi-ku, Tokyo 173, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Female Salicylic Acid / pharmacokinetics* Skin Absorption* Swine |
| Chemical | |
Reg. No./Substance:
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69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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