Document Detail

The percutaneous absorption of salicylic acid.
MedLine Citation:
PMID:  15633967     Owner:  NLM     Status:  MEDLINE    
The present paper reports on the penetration of salicylic acid, a substance with high permeability, through swine skin. Liquid scintillation counter and autoradiographic measurements were performed, on the excised swine skin to which ointment had been applied. The results indicated that the substance penetrated mainly through transfollicular route and was deposited transiently at various levels of each follicle, resulting in zig-zag pattern on the liquid scintillation counter curve. The autoradiographic study also revealed a heavy transfollicular pattern of the substance though a slight transepidermal pattern was also noted. Whether the substance penetrates because of its lipid solubility or because of its affinity to the keratinous tissue is still open to question.
H Takahashi; T Ishii; K Tanabe; H Ikeda
Related Documents :
1596717 - Knotting technique and suture materials.
7113547 - Influence of anti-rheumatic drugs on the activity of collagenolytic cathepsin in hepati...
23924187 - Computational design of an unnatural amino acid dependent metalloprotein with atomic le...
21111517 - Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproli...
20056317 - Rapid determination of the toxicity of quantum dots with luminous bacteria.
16345727 - Physiological criteria and mycotoxin production as aids in identification of common asy...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  3     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  2005-01-06     Completed Date:  2005-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Department of Dermatology, School of Medicine, Teikyo University, Kaga-2, Itabashi-ku, Tokyo 173, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Salicylic Acid / pharmacokinetics*
Skin Absorption*
Reg. No./Substance:
69-72-7/Salicylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrastructure of the microvasculature in skin affected by systemic scleroderma.
Next Document:  Triple fungal infection--chronic mucocutaneous candidiasis, exophytic dermatophytosis and cryptococc...