Document Detail

The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma.
MedLine Citation:
PMID:  14561019     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators. STUDY OBJECTIVE: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance. METHODS: The POD was measured in 26 mild moderate asthmatic patients following bronchodilation, using beta2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude. RESULTS: The increase in forced expiratory volume in 1 s (FEV1), 30 min after the inhalation of beta2-agonist (mean +/- SEM 22.3 +/- 0.8%), was associated with a statistically significant decrease (P < 0.005) in the POD. The mean decrease in FEV1 following methacoline challenge, was 23 +/- 0.7% and was followed by a statistically significant increase (P < 0.005) in the POD. The magnitude of the decrease in the POD following albuterol was almost identical to the magnitude of the increase in the POD following methacholine. CONCLUSIONS: In stable mild-moderate asthmatic patients, the changes in the magnitude of dyspnea, perceived by a subject, is independent on the direction of the change in the FEV1.
Paltiel Weiner; Marinella Beckerman; Noa Berar-Yanay; Rasmi Magadle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  97     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-16     Completed Date:  2003-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1120-5     Citation Subset:  IM    
Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel.
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MeSH Terms
Asthma / physiopathology*
Bronchial Provocation Tests
Bronchoconstriction / drug effects,  physiology
Bronchoconstrictor Agents / adverse effects*,  diagnostic use
Bronchodilator Agents / adverse effects*
Dyspnea / chemically induced*,  psychology
Forced Expiratory Volume / drug effects
Methacholine Chloride / diagnostic use
Receptors, Adrenergic, beta-2 / antagonists & inhibitors
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Receptors, Adrenergic, beta-2; 62-51-1/Methacholine Chloride

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