| The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma. | |
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MedLine Citation:
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PMID: 14561019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is well documented that the perception of dyspnea (POD), subjectively reported by patients, is an important index used to guide treatment. The severity of dyspnea following methacholine-induced bronchoconstriction and added mechanical loads is increasing in popular. No formal attention has been addressed to the reduction in dyspnea following bronchodilators. STUDY OBJECTIVE: To investigate if the magnitude of dyspnea perceived by a subject is independent on the direction (e.g., bronchoconstriction or bronchodilation) of the change in airway resistance. METHODS: The POD was measured in 26 mild moderate asthmatic patients following bronchodilation, using beta2-agonists, and following bronchoconstriction, induced by methacholine challenge, to almost the same magnitude. RESULTS: The increase in forced expiratory volume in 1 s (FEV1), 30 min after the inhalation of beta2-agonist (mean +/- SEM 22.3 +/- 0.8%), was associated with a statistically significant decrease (P < 0.005) in the POD. The mean decrease in FEV1 following methacoline challenge, was 23 +/- 0.7% and was followed by a statistically significant increase (P < 0.005) in the POD. The magnitude of the decrease in the POD following albuterol was almost identical to the magnitude of the increase in the POD following methacholine. CONCLUSIONS: In stable mild-moderate asthmatic patients, the changes in the magnitude of dyspnea, perceived by a subject, is independent on the direction of the change in the FEV1. |
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Authors:
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Paltiel Weiner; Marinella Beckerman; Noa Berar-Yanay; Rasmi Magadle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiratory medicine Volume: 97 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-16 Completed Date: 2003-12-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1120-5 Citation Subset: IM |
Affiliation:
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Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel. weiner@hillel-yaffe.health.gov.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / physiopathology* Bronchial Provocation Tests Bronchoconstriction / drug effects, physiology Bronchoconstrictor Agents / adverse effects*, diagnostic use Bronchodilator Agents / adverse effects* Dyspnea / chemically induced*, psychology Female Forced Expiratory Volume / drug effects Humans Male Methacholine Chloride / diagnostic use Perception Receptors, Adrenergic, beta-2 / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Receptors, Adrenergic, beta-2; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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