Document Detail


The peptidoglycan sacculus of Myxococcus xanthus has unusual structural features and is degraded during glycerol-induced myxospore development.
MedLine Citation:
PMID:  18996994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Upon nutrient limitation cells of the swarming soil bacterium Myxococcus xanthus form a multicellular fruiting body in which a fraction of the cells develop into myxospores. Spore development includes the transition from a rod-shaped vegetative cell to a spherical myxospore and so is expected to be accompanied by changes in the bacterial cell envelope. Peptidoglycan is the shape-determining structure in the cell envelope of most bacteria, including myxobacteria. We analyzed the composition of peptidoglycan isolated from M. xanthus. While the basic structural elements of peptidoglycan in myxobacteria were identical to those in other gram-negative bacteria, the peptidoglycan of M. xanthus had unique structural features. meso- or LL-diaminopimelic acid was present in the stem peptides, and a new modification of N-acetylmuramic acid was detected in a fraction of the muropeptides. Peptidoglycan formed a continuous, bag-shaped sacculus in vegetative cells. The sacculus was degraded during the transition from vegetative cells to glycerol-induced myxospores. The spherical, bag-shaped coats isolated from glycerol-induced spores contained no detectable muropeptides, but they contained small amounts of N-acetylmuramic acid and meso-diaminopimelic acid.
Authors:
Nhat Khai Bui; Joe Gray; Heinz Schwarz; Peter Schumann; Didier Blanot; Waldemar Vollmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  Journal of bacteriology     Volume:  191     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-02     Completed Date:  2009-01-23     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-505     Citation Subset:  IM    
Affiliation:
Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacterial Proteins / chemistry*,  metabolism*
Carbohydrate Sequence
Glycerol / metabolism*
Molecular Sequence Data
Myxococcus xanthus / chemistry*,  growth & development,  metabolism
Peptidoglycan / chemistry*,  metabolism*
Spores, Bacterial / chemistry,  growth & development*,  metabolism
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Peptidoglycan; 56-81-5/Glycerol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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