| The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro. | |
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MedLine Citation:
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PMID: 1995186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peptide pyroGlu-Gln-Gly-Ser-Asn, recently isolated from mouse liver, inhibited DNA synthesis and proliferation in vitro of MH1C1 cells, a rat clonal strain derived from a Morris transplantable hepatoma. Both the biological peptide isolated from mouse liver and the synthetic homolog showed bell-shaped dose-response curves. Maximal inhibition (approximately 50%) was observed at two separate dose ranges: one at 10(-7)-10(-10) M, and one at 10(-14)-10(-15) M. |
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Authors:
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J E Paulsen; K Sundby-Hall; L Endresen; H E Rugstad; K L Reichelt; K Elgjo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Carcinogenesis Volume: 12 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-25 Completed Date: 1991-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-10 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Rikshospitalet, Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cell Division / drug effects DNA / biosynthesis Dose-Response Relationship, Drug Liver / chemistry, cytology, drug effects*, metabolism Liver Neoplasms, Experimental / drug therapy, pathology* Mice Molecular Sequence Data Neoplasm Transplantation Oligopeptides / pharmacology* Peptides / isolation & purification, pharmacology* Pyrrolidonecarboxylic Acid / analogs & derivatives Rats Time Factors Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/Peptides; 129276-53-5/pyroglutamyl-glutaminyl-glycyl-seryl-asparagine; 9007-49-2/DNA; 98-79-3/Pyrrolidonecarboxylic Acid |
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