Document Detail

The pentose phosphate pathway in regenerating skeletal muscle.
MedLine Citation:
PMID:  629775     Owner:  NLM     Status:  MEDLINE    
1. The activities of the oxidative enzymes (glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) and of the non-oxidative enzymes (transaldolase, tranketolase, ribose 5 phosphate isomerase and ribulose 5-phosphate 3-epimerase) of the pentose phosphate pathway were measured at various times during the first 24h of skeletal-muscle regeneration after administration of Marcaine, a mytoxic local anesthetic. 2. The activities of the oxidative enzymes increased after Marcaine injection and rose to 9 times control activities by 24h. 3. The activities of all non-oxidative enzymes were increased after Marcaine administration, but to a much smaller extent than the oxidative enzymes (1.1-1.7-fold). 4. Histochemical analysis localized glucose 6-phosphate dehydrogenase activity within muscle fibres of control and Marcaine-treated muscles. 5. Cycloheximide or actinomycin D prevented the increase in oxidative enzyme activities, suggesting a requirement for synthesis of protein and RNA.
K R Wagner; F C Kauffman; S R Max
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Biochemical journal     Volume:  170     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM; S    
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MeSH Terms
Bupivacaine / pharmacology
Cycloheximide / pharmacology
Dactinomycin / pharmacology
Enzyme Activation / drug effects
Glucosephosphate Dehydrogenase / metabolism
Glucuronidase / metabolism
Muscles / drug effects,  physiology*
Pentosephosphates / metabolism*
Phosphogluconate Dehydrogenase / metabolism
Reg. No./Substance:
0/Pentosephosphates; 2180-92-9/Bupivacaine; 50-76-0/Dactinomycin; 66-81-9/Cycloheximide; EC Dehydrogenase; EC Dehydrogenase; EC

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