| The penis is not protected--in hypertension there are vascular changes in the penis which are similar to those in other vascular beds. | |
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MedLine Citation:
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PMID: 10404281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In hypertension, small arteries in a variety of vascular beds undergo structural changes that increase resistance. To assess whether there are differential structural changes in the penis that accompany hypertension, we began with determining structurally-based vascular resistance properties in penile and hindlimb vascular beds of adult spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats. In anesthetized SHR, the penile and hindlimb vasculature were isolated and perfused, maximum dilation was induced, and a flow-pressure assessment and alpha 1-adrenoceptor agonist concentration-response curves were generated. Both the baseline and maximum constrictor responses were similar in the two beds of each strain, and overall the maximum structurally-based vascular resistance in SHR was higher than in SD rats. Our data suggests that the penile vasculature is not protected from the structural changes that take place in the other vascular beds in hypertension. There does not appear to be an underlying functional control mechanism that protects the penile vasculature from structural changes that may have a negative impact on penile blood flow. |
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Authors:
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H Okabe; T M Hale; H Kumon; J P Heaton; M A Adams |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of impotence research Volume: 11 ISSN: 0955-9930 ISO Abbreviation: Int. J. Impot. Res. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-08-26 Completed Date: 1999-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007383 Medline TA: Int J Impot Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 133-40 Citation Subset: IM |
Affiliation:
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Department of Pharmacology & Toxicology and Urology, Queen's University, Kinston, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hindlimb / blood supply Hypertension / pathology*, physiopathology Male Penis / blood supply* Rats Rats, Inbred SHR Rats, Sprague-Dawley Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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