Document Detail

The penetration of inulin, sucrose, mannitol and tritiated water from the interstitial space in muscle into the vascular system.
MedLine Citation:
PMID:  5503509     Owner:  NLM     Status:  MEDLINE    
1. An isolated gastrocnemius muscle from cat was perfused with a modified Ringer fluid containing the extracellular tracers mannitol, sucrose and inulin and in some cases tritiated water (HTO). When equilibration of the tracers between the perfusate and the tissue was obtained, perfusion with tracer-free fluid was started.2. The fractional rate of escape, Phi (t), of the tracers was followed. For all tracers it declined steadily with time. The rate of decline was faster for the smaller extracellular molecules when any combination of two extracellular tracers was studied.3. Arrest of flow for 1-2 min lead to an increase in Phi (t) for the extracellular tracers when flow was resumed. There was little or no effect upon Phi (t) for HTO.4. Doubling the rate of flow had no effect upon Phi (t) for the extracellular tracers, while that of HTO increased.5. We conclude that the cause of the decline in Phi (t) for the extracellular tracers is concentration gradients in the interstitial space. The findings raise problems in methods for studying capillary permeability by means of the fractional rate of escape of tracers from the interstitial space into the vascular system.
C Crone; D Garlick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  210     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1971-04-25     Completed Date:  1971-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  387-404     Citation Subset:  IM    
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MeSH Terms
Capillary Permeability*
Carbon Isotopes
Extracellular Space
Inulin / metabolism*
Mannitol / metabolism*
Muscles / metabolism*
Sucrose / metabolism*
Time Factors
Water / metabolism*
Reg. No./Substance:
0/Carbon Isotopes; 10028-17-8/Tritium; 57-50-1/Sucrose; 69-65-8/Mannitol; 7732-18-5/Water; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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