| IgG/IgA pemphigus with dyskeratotic acantholysis and intraepidermal neutrophilic microabscesses. | |
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MedLine Citation:
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PMID: 17973815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpetiform vesicles and erythema with erosion developed on the trunk of a 48-year-old Japanese man. Acantholysis was observed in the spinous layer of the lesional epidermis and direct immunofluorescence revealed cell surface deposition of immunoglobulin IgG and C3. Indirect immunofluorescence could not detect circulating anti-cell surface antibodies. Immunoblot analysis detected neither anti-desmoglein (Dsg)1 antibody nor anti-Dsg3 antibody. Enzyme-linked immunosorbent assay could detect IgG and IgA anti-Dsg1 antibodies and IgA anti-Dsg3 antibody, in addition to a gray zone titer of IgG anti-Dsg3 antibody. Intraepidermal neutrophilic infiltration with neutrophilic microabscesses and intense dyskeratotic cells were histopathologically characteristic in this case. Skin lesions improved within 1 month and remission has continued for 9 years under oral administration of dapsone. |
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Authors:
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Kimiko Nakajima; Takashi Hashimoto; Hideki Nakajima; Maki Yokogawa; Mitsunori Ikeda; Hajime Kodama |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 34 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-01 Completed Date: 2008-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: Japan |
Other Details:
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Languages: eng Pagination: 757-60 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Kochi Medical School, Nankoku, Kochi, Japan. nakajimk@kochi-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acantholysis
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pathology Autoantibodies / blood Dapsone / therapeutic use Desmoglein 1 / immunology Desmoglein 3 / immunology Folic Acid Antagonists / therapeutic use Humans Immunoglobulin A / blood* Immunoglobulin G / blood* Immunologic Tests Male Middle Aged Neutrophils Pemphigus / drug therapy, immunology, pathology* Skin / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Desmoglein 1; 0/Desmoglein 3; 0/Folic Acid Antagonists; 0/Immunoglobulin A; 0/Immunoglobulin G; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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