Document Detail


A peer-education intervention to reduce injection risk behaviors for HIV and hepatitis C virus infection in young injection drug users.
MedLine Citation:
PMID:  17721100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate whether a behavioral intervention, which taught peer education skills, could reduce injection and sexual risk behaviors associated with primary HIV and hepatitis C virus infection (HCV) among young injection drug users (IDU). DESIGN: We conducted a randomized controlled trial involving HIV and HCV antibody-negative IDU, aged 15-30 years, recruited in five United States cities. A six-session, small-group, cognitive behavioral, skills-building intervention in which participants were taught peer education skills (n = 431) was compared with a time-equivalent attention control (n = 423). Baseline visits included interviews for sociodemographic, psychosocial, and behavioral factors during the previous 3 months; HIV and HCV antibody testing; and pre/posttest counselling. Procedures were repeated 3 and 6 months postintervention. RESULTS: The intervention produced a 29% greater decline in overall injection risk 6 months postintervention relative to the control [proportional odds ratio 0.71; 95% confidence limit (CL) 0.52, 0.97], and a 76% decrease compared with baseline. Decreases were also observed for sexual risk behaviors, but they did not differ by trial arm. Overall HCV infection incidence (18.4/100 person-years) did not differ significantly across trial arms (relative risk 1.15; 95% CL 0.72, 1.82). No HIV seroconversions were observed. CONCLUSION: Interventions providing information, enhancing risk-reduction skills, and motivating behavior change through peer education training can reduce injection risk behaviors, although risk elimination might be necessary to prevent HCV transmission.
Authors:
Richard S Garfein; Elizabeth T Golub; Alan E Greenberg; Holly Hagan; Debra L Hanson; Sharon M Hudson; Farzana Kapadia; Mary H Latka; Lawrence J Ouellet; David W Purcell; Steffanie A Strathdee; Hanne Thiede;
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AIDS (London, England)     Volume:  21     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-11-08     Revised Date:  2008-01-31    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1923-32     Citation Subset:  IM; X    
Affiliation:
Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. rgarfein@ucsd.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00164372
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adolescent Behavior / psychology
Adult
Behavior Therapy / methods
Female
HIV Infections / epidemiology,  prevention & control*
Health Education / methods*
Hepatitis C / epidemiology,  prevention & control*
Humans
Incidence
Male
Peer Group*
Risk Reduction Behavior*
Sexual Behavior / psychology
Substance Abuse, Intravenous / epidemiology,  psychology*
Treatment Outcome
United States / epidemiology
Grant Support
ID/Acronym/Agency:
U64 CCU217659//PHS HHS; U64/CCU017615//PHS HHS; U64/CCU317662//PHS HHS; U64/CCU517656//PHS HHS; U64/CCU917655//PHS HHS
Comments/Corrections
Comment In:
AIDS. 2007 Sep 12;21(14):1967-9   [PMID:  17721105 ]
AIDS. 2008 Jan 11;22(2):319; author reply 319   [PMID:  18097240 ]

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