Document Detail


A pedigree-based study of mitochondrial D-loop DNA sequence variation among Arabian horses.
MedLine Citation:
PMID:  10690354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Through DNA sequence comparisons of a mitochondrial D-loop hypervariable region, we investigated matrilineal diversity for Arabian horses in the United States. Sixty-two horses were tested. From published pedigrees they traced in the maternal line to 34 mares acquired primarily in the mid to late 19th century from nomadic Bedouin tribes. Compared with the reference sequence (GenBank X79547), these samples showed 27 haplotypes with altogether 31 base substitution sites within 397 bp of sequence. Based on examination of pedigrees from a random sampling of 200 horses in current studbooks of the Arabian Horse Registry of America, we estimated that this study defined the expected mtDNA haplotypes for at least 89% of Arabian horses registered in the US. The reliability of the studbook recorded maternal lineages of Arabian pedigrees was demonstrated by haplotype concordance among multiple samplings in 14 lines. Single base differences observed within two maternal lines were interpreted as representing alternative fixations of past heteroplasmy. The study also demonstrated the utility of mtDNA sequence studies to resolve historical maternity questions without access to biological material from the horses whose relationship was in question, provided that representatives of the relevant female lines were available for comparison. The data call into question the traditional assumption that Arabian horses of the same strain necessarily share a common maternal ancestry.
Authors:
A T Bowling; A Del Valle; M Bowling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal genetics     Volume:  31     ISSN:  0268-9146     ISO Abbreviation:  Anim. Genet.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-17     Completed Date:  2000-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA, Mitochondrial / genetics*
Female
Haplotypes / genetics
Horses / genetics*
Pedigree
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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