| The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity. | |
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MedLine Citation:
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PMID: 15265159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune-mediated and structural/genetic factors. |
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Authors:
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Asher D Schachter |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric transplantation Volume: 8 ISSN: 1397-3142 ISO Abbreviation: Pediatr Transplant Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-21 Completed Date: 2005-01-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9802574 Medline TA: Pediatr Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 344-8 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Blackwell Munksgaard |
Affiliation:
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Children's Hospital Informatics Program, Division of Nephrology, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. asher.schachter@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actinin
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blood Child Genetic Heterogeneity Humans Interferon-gamma / blood Interleukin-12 / blood Interleukin-13 / blood Interleukin-15 / blood Interleukin-18 / blood Interleukin-2 / blood Interleukin-4 / blood Intracellular Signaling Peptides and Proteins Membrane Proteins / blood Microfilament Proteins / blood NF-kappa B / blood Nephrotic Syndrome / blood*, genetics*, pathology Proteins / analysis Transforming Growth Factor beta / blood Tumor Necrosis Factor-alpha / analysis |
| Grant Support | |
ID/Acronym/Agency:
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K23 RR016080-04/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ACTN4 protein, human; 0/Interleukin-13; 0/Interleukin-15; 0/Interleukin-18; 0/Interleukin-2; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Microfilament Proteins; 0/NF-kappa B; 0/NPHS2 protein; 0/Proteins; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 0/nephrin; 11003-00-2/Actinin; 187348-17-0/Interleukin-12; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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