| The patterns of glucose tolerance and insulin resistance among rural Chinese twin children, adolescents, and young adults. | |
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MedLine Citation:
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PMID: 20580383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pubertal insulin resistance (IR) is well recognized; but little data are available for glucose and insulin pattern from a large, unselected lean population. This report describes the age- and sex-specific distributions of glucose tolerance and IR in a rural Chinese twin population. This report includes 4488 subjects aged 6 to 24 years. The primary variables of interest are fasting plasma glucose, 2-hour postload plasma glucose (2-h PG), fasting serum insulin, 2-hour postload insulin, and the homeostatic model assessment for IR. Age- and sex-specific patterns for the primary variables are described using smoothing plot, arithmetic or geometric mean, and percentiles. There is an increase in fasting plasma glucose, 2-h PG, and IR during puberty (10-19 years) and a return to prepuberty level by the age of 20 years. Insulin resistance peaks at around the age of 14 years in girls and 16 years in boys. Two-hour postload plasma glucose and 2-hour postload insulin are higher in girls than in boys from early puberty, and the sex differences are more pronounced afterward. Moreover, the prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) increases after puberty and is higher in girls than in boys. In this community-based, nonobese rural Chinese twin population, we observed sex-specific remarkable pubertal surge of IR and modest increase in plasma glucose as well as increasing prevalence of IFG and IGT with age. Notably, females had higher 2-h PG and higher prevalence of IFG and IGT. Our study underscored that adolescence (even more so in females) is a critical period for developing IR and prediabetes. |
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Authors:
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Guoying Wang; Binyan Wang; Fengxiu Ouyang; Xue Liu; Gengfu Tang; Houxun Xing; Zhiping Li; Xiping Xu; Xiaobin Wang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Twin Study Date: 2010-06-26 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 59 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1752-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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The Mary Ann & J Milburn Smith Child Health Research Program, Children's Memorial Hospital/Children's Memorial Research Center, Chicago, IL 60614, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Glucose / metabolism Child China Fasting Female Glucose Tolerance Test* Humans Insulin / blood Insulin Resistance* Male Rural Population* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG032227/AG/NIA NIH HHS; R01 AG032227-04/AG/NIA NIH HHS; R01 HD049059/HD/NICHD NIH HHS; R01 HD049059-04/HD/NICHD NIH HHS; R01 HL086461/HL/NHLBI NIH HHS; R01 HL086461-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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