Document Detail

The pattern of recurrent colorectal cancer in a prospective randomised study and the characteristics of diagnostic tests.
MedLine Citation:
PMID:  9457525     Owner:  NLM     Status:  MEDLINE    
In a prospective randomised study, 597 patients subjected to curative surgery for colorectal cancer were allocated to either a group with frequent follow-up or a control group with follow-up every 5 years. The pattern of recurrence is reviewed. An equal number of recurrences was detected in the two groups, but the recurrence was diagnosed 9 months earlier in patients followed frequently, and the diagnostic characteristics of various tests dependent upon how often they were used. It is unlikely that frequent follow-up after curative surgery for colorectal cancer has a large positive influence upon survival, but a small benefit from an intensive follow-up program cannot be ruled out. The present results indicate that clinical examination, digital rectal examination, proctoscopy, colonoscopy and chest x-ray should be included in such a programme, whereas others (blood haemoglobin, faecal occult blood test, double contrast braium enema, serum alanine aminotransferase, and serum bilirubin) should be avoided, having a low sensitivity for detecting recurrent colorectal cancer.
B J Kjeldsen; O Kronborg; C Fenger; O D Jørgensen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of colorectal disease     Volume:  12     ISSN:  0179-1958     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  IM    
Department of Surgery A, Odense University Hospital, Denmark.
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MeSH Terms
Colorectal Neoplasms / diagnosis*,  surgery
Follow-Up Studies
Middle Aged
Neoplasm Recurrence, Local / diagnosis*
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity

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