Document Detail

The pattern of neural tube defects created by secondary reopening of the neural tube.
MedLine Citation:
PMID:  2246488     Owner:  NLM     Status:  MEDLINE    
The usual location of human neural tube defects at the rostral or caudal end of the primary neural tube suggests they are caused by failure of closure of the neural tube. In this study, neural tube defects were created by surgical reopening of the neural tube of 3-day-old duck embryos in one of three sites: the forebrain, cervicothoracic region, or thoracolumbar region. It was determined that of the 31 survivors with forebrain incisions, 39% had exencephaly; of the 42 survivors with thoracolumbar incisions, 31% had myeloschisis; but of the 37 with a cervicothoracic incision, only 14% had exposed spinal cord. This indicates that a rostral-caudal distribution of neural tube defects can be seen in a model created by secondary reopening of the neural tube.
L R Campbell; G S Sohal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  5     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-10     Completed Date:  1991-01-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  336-40     Citation Subset:  IM    
Department of Neurology and Pediatrics, Medical College of Georgia, Augusta 30912-3255.
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MeSH Terms
Anencephaly / embryology
Brain / embryology
Meningomyelocele / embryology
Nerve Regeneration / physiology*
Neural Tube Defects / embryology*
Spinal Cord / embryology

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