| The pattern of growth hormone delivery to peripheral tissues determines insulin-like growth factor-1 and lipolytic responses in obese subjects. | |
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MedLine Citation:
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PMID: 19470622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: It is unclear whether the pattern of GH delivery to peripheral tissues has important effects. OBJECTIVE: The aim of the study was to compare the effects of pulsatile vs. continuous administration of GH upon metabolic and IGF-I parameters in obese subjects. SETTING: The study was conducted at the General Clinical Research Center at the University of Michigan Medical Center. PARTICIPANTS: Four men and five women with abdominal obesity (body mass index, 33 +/- 3 kg/m(2); body fat, 40 +/- 3%) participated in the study. INTERVENTION: GH (0.5 mg/m(2) . d) was given iv for 3 d as: 1) continuous infusion (C); and 2) pulsatile boluses (P) (15% of the dose at 0700, 1300, and 1800 h and 55% at 2400 h). These trials were preceded by a basal period (B) when subjects received normal saline. MAIN OUTCOME MEASURES: Rate of lipolysis and hepatic glucose production were evaluated using stable isotope tracer techniques. The composite index of insulin sensitivity (Matsuda index) was assessed using oral glucose tolerance test. RESULTS: The increase in plasma IGF-I concentrations was greater (P < 0.05) with continuous GH infusion (211 +/- 31, 423 +/- 38, and 309 +/- 34 microg/liter for B, C, and P, respectively). Muscle IGF-I mRNA was significantly increased (P < 0.05) only after the continuous GH infusion (1.2 +/- 0.4, 4.4 +/- 1.3, and 2.3 +/- 0.6 arbitrary units, for B, C, and P, respectively). Only pulsatile GH augmented the rate of lipolysis (4.1 +/- 0.3, 4.8 +/- 0.7, and 7.1 +/- 1.1 mumol/kg . min for B, C, and P, respectively). GH had no effect on hepatic glucose production, but both modes of GH administration were equally effective in impairing insulin sensitivity. CONCLUSION: These findings indicate that, in obese subjects, discrete components of GH secretory pattern may differentially affect IGF-I generation and lipolytic responses. |
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Authors:
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Sowmya Surya; Jeffrey F Horowitz; Naila Goldenberg; Alla Sakharova; Matthew Harber; Andrea S Cornford; Kathy Symons; Ariel L Barkan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-05-26 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 94 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-06 Completed Date: 2009-08-25 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2828-34 Citation Subset: AIM; IM |
Affiliation:
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Division of Metabolism, Endocrinology and Diabetes, University of Michigan, 3920 Taubman Center, Ann Arbor, MI 48109-5354, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Glucose / metabolism Human Growth Hormone / blood, secretion* Humans Insulin-Like Growth Factor I / analysis* Lipolysis* Male Muscle, Skeletal / chemistry Obesity / metabolism* Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK 071955/DK/NIDDK NIH HHS; UL1 RR 024986/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone; 50-99-7/Glucose; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
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