Document Detail

The pattern of expression of the 5T4 oncofoetal antigen on normal, dysplastic and malignant oral mucosa.
MedLine Citation:
PMID:  11120484     Owner:  NLM     Status:  MEDLINE    
The human 5T4 oncofoetal antigen is expressed by all types of trophoblast in pregnancy but is not detected on most adult tissues, although low levels are found on some epithelia. However, this antigen is strongly expressed by many cancers and tumour-associated labelling correlates with metastatic spread and poor clinical outcome for patients with gastric and colon cancer. Over-expression of the gene influences cell adhesion, shape and motility, which may be related to changes in the cellular localisation of the 5T4 oncofoetal antigen as malignancy develops. To establish whether the 5T4 oncofoetal antigen can serve as a tumour-specific marker for oral cancer and precancer, we have evaluated the pattern of expression on biopsies of normal, inflamed and dysplastic oral mucosa using immunohistochemistry. Oral mucosa, taken from different sites in the mouth, expressed the 5T4 oncofoetal antigen with varying intensity and pattern. The majority of the immunoreactivity was detected in the basal and suprabasal layers, with expression extending into the spinous cells at fully keratinised sites and when inflammation was present. This antigen was also detected in the underlying connective tissue. Oral squamous cell carcinoma showed a variety of patterns and intensity of staining corresponding to those found for normal mucosa. However, 21 of 41 cases showed no stromal labelling, a finding also observed for dysplastic lesions. The alterations in the pattern and intensity of 5T4 oncofoetal antigen expression were not related to clinicopathological features of the tumours examined. These data show that the 5T4 oncofoetal antigen is expressed on normal oral mucosa, such that this target cannot be used for detection of neoplastic or preneoplastic cells, although altered expression may contribute to the pathogenesis of these lesions.
A Ali; J Langdon; P Stern; M Partridge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral oncology     Volume:  37     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Maxillofacial Unit/Molecular Oncology, King's College Hospital, Denmark Hill, SE5 8RX, London, UK.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / metabolism*,  pathology
Disease Progression
Erythroplasia / metabolism
Leukoplakia, Oral / metabolism
Lichen Planus, Oral / metabolism
Lymphatic Metastasis
Membrane Glycoproteins / metabolism*
Middle Aged
Mouth Mucosa / metabolism
Mouth Neoplasms / metabolism*,  pathology
Neoplasm Proteins / metabolism
Precancerous Conditions / metabolism*
Tumor Markers, Biological / metabolism*
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 0/trophoblastic glycoprotein 5T4, human

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