Document Detail


The pattern and clinical manifestations of rheumatoid arthritis in Sarawak General Hospital.
MedLine Citation:
PMID:  18773254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our study is to describe the pattern, clinical features, treatment regimes, and disease activity among the patients treated for rheumatoid arthritis (RA) in the Sarawak General Hospital. We performed a cross-sectional study of all patients with a diagnosis of RA who received treatment at the General Medical Clinic and the Rheumatology Clinic in Sarawak General Hospital over a 1-year period from 1st June 2006 to 31st May 2007. Demographic data, clinical features, and disease activity of all 154 patients were collected for statistical analysis. Rheumatoid arthritis afflicts all the major racial groups in Sarawak including the native population. Our patients have a mean disease duration of 5.4 years (SD 5.69) and a mean duration of delay in diagnosis RA and initiation of disease-modifying antirheumatic drug (DMARD) treatment of 42.9 months (SD 60.1). They have a low rate of interstitial lung disease (6.5%) and rheumatoid nodules (4.5%). Rheumatoid factor was positive in 65.5% of our patients. They have a mean Disease Activity Score (DAS) 28 score of 4.28 (SD 1.33). Only 12.5% of our patients are in remission with DAS 28 < 2.6 and 30.9% of our patients are having high disease activity with DAS 28 > 5.1. Despite the high usage of DMARDs in Sarawak (>80%), our patients have severe disease with high disease activity indices. This is most likely due to delay in diagnosis and initiating DMARDs in RA patients in Sarawak.
Authors:
C L Teh; J S Wong
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Publication Detail:
Type:  Journal Article     Date:  2008-09-05
Journal Detail:
Title:  Clinical rheumatology     Volume:  27     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  1437-40     Citation Subset:  IM    
Affiliation:
Department of Medicine, Sarawak General Hospital, Jalan Hospital, Kuching, Sarawak, Malaysia. tehchenglay@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  epidemiology*,  physiopathology
Female
Hospitals, General / statistics & numerical data
Humans
Malaysia / epidemiology
Male
Middle Aged
Physician's Practice Patterns
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Antirheumatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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