Document Detail

A patient with multiple sclerosis and Down's syndrome with a rare paroxysmal symptom at onset.
MedLine Citation:
PMID:  10362908     Owner:  NLM     Status:  MEDLINE    
Down's syndrome (DS) is often associated with autoimmune diseases, although an association with multiple sclerosis (MS) has not been previously reported. A 49-year-old male with DS experienced progressively worsening gait and bladder dysfunction. Following Poser criteria, the patient was diagnosed with laboratory-supported definite MS. Ten days following diagnosis the patient experienced dysestetic paroxysmal pain at the pelvic level (an uncommon complaint in MS) which was initially addressed with carbamazepine, resulting in mild relief and adverse effects consisting of increased motor deficit and decreased daytime alertness. A titration combination of lamotrigine and gabapentin, two relatively new antiepileptic drugs which have been utilized individually for a number of neurological symptoms, resulted in significant reduction in pain frequency and intensity, with no adverse effects. This case study presents details of the first reported association of DS and MS, between which the pathogenetic relationship remains unclear. The presence of a rare symptom complaint in MS, as well as the effective combination of lamotrigine and gabapentin for treating this symptom, without adverse effects is an additional interesting aspect of this case.
C Solaro; M M Uccelli; G L Mancardi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  6     ISSN:  1351-5101     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  505-7     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Lippincott Williams & Wilkins
Department of Neurological Sciences and Rehabilitation, University of Genoa, Italy.
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MeSH Terms
Acetates / therapeutic use
Brain / pathology
Cyclohexanecarboxylic Acids*
Down Syndrome / complications*,  physiopathology
Excitatory Amino Acid Antagonists / therapeutic use
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis / complications*,  drug therapy,  physiopathology
Pelvic Pain / etiology
Triazines / therapeutic use
gamma-Aminobutyric Acid*
Reg. No./Substance:
0/Acetates; 0/Amines; 0/Cyclohexanecarboxylic Acids; 0/Excitatory Amino Acid Antagonists; 0/Triazines; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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