Document Detail


A patient undergoing chronic dialysis whose renal anemia was successfully corrected by treatment with cinacalcet.
MedLine Citation:
PMID:  21455660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10.0 mg/dL, which caused difficulties in performing vitamin D injection therapy. No parathyroid glands were seen by echography or scintigraphy. On 31 March 2008 her intact PTH (iPTH) level was 895 pg/mL so treatment with cinacalcet 25 mg/day was started. After 3 months her iPTH level decreased to 269 pg/mL and her hemoglobin level increased from 9.3 to 12.9 g/dL. In some cases of severe HPT, anemia improves after parathyroidectomy; however, in this case, cinacalcet improved not only secondary HPT but also anemia.
Authors:
Yoshiyuki Oshiro; Hisataka Tanaka; Niro Okimoto
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-01
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  15     ISSN:  1437-7799     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-17     Completed Date:  2011-12-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  607-10     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Department Internal Medicine, Kawasaki Medical School Kawasaki Hospital, 2-1-80 Nakasange, Kitaku, Okayama, Okayama 700-8505, Japan. y.oshiro@kawasaki-hp.jp
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MeSH Terms
Descriptor/Qualifier:
Anemia / drug therapy,  etiology*
Calcimimetic Agents / therapeutic use*
Female
Humans
Hyperparathyroidism / blood
Hyperparathyroidism, Secondary / etiology*
Kidney Diseases / drug therapy,  etiology*
Kidney Failure, Chronic / complications*
Middle Aged
Naphthalenes / therapeutic use*
Parathyroid Hormone / blood
Parathyroidectomy
Renal Dialysis / adverse effects
Chemical
Reg. No./Substance:
0/Calcimimetic Agents; 0/Naphthalenes; 0/Parathyroid Hormone; UAZ6V7728S/cinacalcet

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