| Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis. | |
| | |
MedLine Citation:
|
PMID: 21910009 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In vitro and in vivo studies have demonstrated that lung cell apoptosis is associated with lung fibrosis; however the relationship between apoptosis of alveolar macrophages (AMs) and human silicosis has not been addressed. In the present study, AM apoptosis was determined in whole-lung lavage fluid from 48 male silicosis patients, 13 male observers, and 13 male healthy volunteers. The relationships between apoptosis index (AI) and silica exposure history, soluble Fas (sFas)/membrane-bound Fas (mFas), and caspase-3/caspase-8 were analyzed. AI, mFas, and caspase-3 were significantly higher in lung lavage fluids from silicosis patients than those of observers or healthy volunteers, but the level of sFas demonstrated a decreasing trend. AI was related to silica exposure, upregulation of mFas, and activation of caspase-3 and -8, as well as influenced by smoking status after adjusting for confounding factors. These results indicate that AM apoptosis could be used as a potential biomarker for human silicosis, and the Fas/FasL pathway may regulate this process. The present data from human lung lavage samples may help to understand the mechanism of silicosis and in turn lead to strategies for preventing or treating this disease. |
| | |
Authors:
|
San-Qiao Yao; Liying Wang Rojanasakul; Zhi-Yuan Chen; Ying-Jun Xu; Yu-Ping Bai; Gang Chen; Xi-Ying Zhang; Chun-Min Zhang; Yan-Qin Yu; Fu-Hai Shen; Ju-Xiang Yuan; Jie Chen; Qin-Cheng He |
Related Documents
:
|
7767949 - Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-... 16216409 - Overexpression of pml induced apoptosis in bladder cancer cell by caspase dependent pat... 11593419 - Protein phosphatase 1alpha-mediated stimulation of apoptosis is associated with dephosp... 22264489 - Microbial transformation of deoxyandrographolide and their inhibitory activity on lps-i... 18922099 - In vivo biological effects of atra in the treatment of aml. 21289219 - Energy, evolution, and human diseases: an overview. 17448999 - The bh3-only protein bid is dispensable for dna damage- and replicative stress-induced ... 16543949 - The neutrophil-activating protein of helicobacter pylori promotes th1 immune responses. 8131779 - Interactions between bacterial lipopolysaccharides and serum lipoproteins and their pos... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-11 |
Journal Detail:
|
Title: Apoptosis : an international journal on programmed cell death Volume: - ISSN: 1573-675X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, China, sanqiaoyao@qq.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon ca...
Next Document: Hepatocellular carcinoma: clinical and radiological findings in patients with chronic B viral hepati...