Document Detail

The pathophysiology of varicocele-associated male infertility.
MedLine Citation:
PMID:  12084227     Owner:  NLM     Status:  MEDLINE    
Varicocele is the most commonly identifiable, surgically correctable lesion associated with male-factor infertility. Surgical correction of a varicocele, whether unilateral or bilateral, results in improvement not only in semen parameters but also in spontaneous and assisted pregnancy rates. Varicoceles seem to induce a number of changes in the testicular microenvironment. These alterations in temperature, hemodynamics, and reactive oxidative species and antioxidant concentrations have been demonstrated to produce deleterious effects on spermatogenesis. However, despite current knowledge in the pathophysiology of varicocele-associated male infertility, the exact mechanism--or mechanisms--by which varicoceles impair fertility remains elusive. This review examines scientific evidence regarding the pathophysiology of varicocele-associated male infertility.
R A Schoor; S M Elhanbly; C Niederberger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current urology reports     Volume:  2     ISSN:  1527-2737     ISO Abbreviation:  Curr Urol Rep     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-06-26     Completed Date:  2002-07-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100900943     Medline TA:  Curr Urol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-6     Citation Subset:  IM    
Department of Urology/Andrology, Division of Andrology, University of Illinois at Chicago, 840 South Wood Street, M/C 955, Chicago, IL 60612-7316, USA.
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MeSH Terms
Infertility, Male / etiology*,  physiopathology*
Varicocele / complications*,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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