| The pathophysiology of shock in anaphylaxis. | |
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MedLine Citation:
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PMID: 17493496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The balance of evidence from human observations and animal studies suggests that the main pathophysiologic features of anaphylactic shock are a profound reduction in venous tone and fluid extravasation causing reduced venous return (mixed hypovolemic-distributive shock) and depressed myocardial function. Aggressive fluid resuscitation is required to ameliorate hypovolemic-distributive shock, and an intravenous infusion of epinephrine will increase vascular tone, myocardial contractility, and cardiac output in most cases. Where these measures fail, pathophysiologic considerations and anecdotal evidence support the consideration of selective vasoconstrictors as the next step in treatment. |
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Authors:
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Simon G A Brown |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunology and allergy clinics of North America Volume: 27 ISSN: 0889-8561 ISO Abbreviation: Immunol Allergy Clin North Am Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-11 Completed Date: 2007-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8805635 Medline TA: Immunol Allergy Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 165-75, v Citation Subset: IM |
Affiliation:
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Emergency Medicine Research Unit, The University of Western Australia and Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia. simon.brown@uwa.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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complications* Animals Humans Shock / etiology*, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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