Document Detail

The pathophysiology of shock in anaphylaxis.
MedLine Citation:
PMID:  17493496     Owner:  NLM     Status:  MEDLINE    
The balance of evidence from human observations and animal studies suggests that the main pathophysiologic features of anaphylactic shock are a profound reduction in venous tone and fluid extravasation causing reduced venous return (mixed hypovolemic-distributive shock) and depressed myocardial function. Aggressive fluid resuscitation is required to ameliorate hypovolemic-distributive shock, and an intravenous infusion of epinephrine will increase vascular tone, myocardial contractility, and cardiac output in most cases. Where these measures fail, pathophysiologic considerations and anecdotal evidence support the consideration of selective vasoconstrictors as the next step in treatment.
Simon G A Brown
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  27     ISSN:  0889-8561     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-75, v     Citation Subset:  IM    
Emergency Medicine Research Unit, The University of Western Australia and Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia.
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MeSH Terms
Anaphylaxis / complications*
Shock / etiology*,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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