| The pathophysiology of peri-operative myocardial infarction. | |
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MedLine Citation:
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PMID: 20528842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is generally believed that plaque rupture and myocardial oxygen supply-demand imbalance contribute approximately equally to the burden of peri-operative myocardial infarction. This review critically analyses data of post-mortem, pre-operative coronary angiography, troponin surveillance, other pre-operative non-invasive investigations, and peri-operative haemodynamic predictors of myocardial ischaemia and/or myocardial infarction. The current evidence suggests that myocardial oxygen supply-demand imbalance predominates in the early postoperative period. It is likely that flow stagnation and thrombus formation is an important pathway in the development of a peri-operative myocardial infarction, in addition to the more commonly recognised role of peri-operative tachycardia. Research and therapeutic interventions should be focused on the prediction and therapy of flow stagnation and thrombus formation. Plaque rupture appears to be a more random event, distributed over the entire peri-operative admission. |
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Authors:
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B M Biccard; R N Rodseth |
Publication Detail:
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Type: Journal Article; Review Date: 2010-06-07 |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-08-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 733-41 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthetics, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Inkosi Albert Luthuli Central Hospital, South Africa. biccardb@ukzn.ac.za |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Coronary Angiography Coronary Circulation / physiology Humans Myocardial Infarction / etiology, physiopathology* Myocardial Ischemia / diagnosis Postoperative Complications / physiopathology* Preoperative Care / methods Troponin / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Troponin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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