| The pathophysiology and epidemiology of myocardial infarction. A review. | |
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MedLine Citation:
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PMID: 1718697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial infarction continues to represent a major cause of death in the Western world, and although there have been significant reductions in its incidence in recent years, some countries such as Scotland and Finland still have high mortality rates. Thrombotic occlusion, in association with varying degrees of plaque disruption and coronary artery spasm, represents the major cause of acute myocardial infarction (AMI). At the cellular level, this results in a shift towards anaerobic metabolism, depletion of energy stores, disrupted membrane integrity, alterations in ionic gradients, myocyte oedema, inhibition of contraction and a proarrhythmic potential. Reperfusion can exacerbate the damage, producing calcium ion accumulation and free radical generation. Infarct expansion and ventricular remodelling can often follow AMI as can additional necrosis, in the form of infarct extension/reinfarction. Rational and optimal treatment of AMI should be based on an understanding of the epidemiological influences and the pathophysiological processes involved. This review considers some of the important features in the pre-, peri- and postinfarction periods. |
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Authors:
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J Gill |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 42 Suppl 2 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1991 |
Date Detail:
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Created Date: 1991-12-17 Completed Date: 1991-12-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Adis Drug Information Services, Chester, Cheshire, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Finland
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epidemiology Heart / physiopathology Humans Myocardial Infarction / epidemiology, physiopathology* Myocardial Reperfusion Injury / physiopathology Myocardium / metabolism Scotland / epidemiology |
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