Document Detail

The pathophysiological changes of experimental fat embolism: early pre-hypoxaemic changes.
MedLine Citation:
PMID:  831959     Owner:  NLM     Status:  MEDLINE    
Glyceryl trioleate has been injected into greyhounds as a model of the fat embolism syndrome. Pulmonary vascular pressures, systemic arterial pressure and cardiac output were determined at regular intervals over an 8-hour period. It has been shown that glyceryl tioleate causes an increased pulmonary vascular resistance and a fall in cardiac output. These effects are mediated partly by a direct mechanical block of pulmonary vessels and partly through a thrombogenic property of the injected fat. The relevance of these findings to the clinical situation is discussed and a sequence of events for the fat embolism syndrome is proposed.
J Sikorski; B J Pardy; J W Bradfield; H A Dudley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  64     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-03-21     Completed Date:  1977-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / etiology,  physiopathology
Blood Pressure
Cardiac Output
Embolism, Fat / chemically induced,  pathology,  physiopathology*
Lung / pathology
Myocardium / pathology
Pulmonary Artery
Time Factors
Vascular Resistance
Reg. No./Substance:

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