| A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography. | |
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MedLine Citation:
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PMID: 17921529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS; Our study aims to investigate the pathophysiologic mechanism underlying tako-tsubo cardiomyopathy using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). METHODS AND RESULTS: Fifteen patients with tako-tsubo cardiomyopathy were enrolled in this study. Plasma catecholamines, cardiac troponin T (cTnT), and D-dimer were serially evaluated in all patients. Thallium-201 ((201)Tl) single-photon emission computed tomography (SPECT) and F-18 FDG PET were performed in 10 and eight patients, respectively. Emotional or physical stress occurred in 12 (80.0%) patients. ST-T segment abnormalities existed in all patients. Thirteen patients exhibited mildly elevated cTnT, although coronary angiography did not reveal significant stenosis in any patient. Endomyocardial biopsy specimens (n = 9) demonstrated contraction-band necrosis (n = 4) and mononuclear cell infiltration (n = 3). The levels of norepinephrine and epinephrine peaked on admission (744 +/- 452 and 140 +/- 166 pg/mL, respectively). There was severely reduced uptake at the apex on F-18 FDG PET image, despite slightly reduced uptake of (201)Tl. Elevation of D-dimer was observed in nine patients. CONCLUSION: The extent of metabolic defect involving apical akinetic area was more severe than perfusion abnormality. Our data suggest that sudden emotional or physical stress may cause a catecholamine-induced metabolic disorder in the myocardium, which is probably central to this syndrome. |
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Authors:
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Tetsuro Yoshida; Takeshi Hibino; Nobuo Kako; Shunsuke Murai; Mitsutoshi Oguri; Kimihiko Kato; Kazuhiro Yajima; Nobuyuki Ohte; Kiyoshi Yokoi; Genjiro Kimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-07 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-02 Completed Date: 2008-06-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 2598-604 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Gifu Prefectural Government Tajimi Hospital, 5-161 Maehata, Tajimi, Gifu 5078522, Japan. tetsuro-moet@nifty.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Catecholamines / blood Coronary Angiography / methods Echocardiography / methods Electrocardiography / methods Female Fibrin Fibrinogen Degradation Products / metabolism Fluorodeoxyglucose F18 / diagnostic use Heart Catheterization / methods Humans Male Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Takotsubo Cardiomyopathy / etiology, metabolism, radionuclide imaging* Thallium Radioisotopes / diagnostic use Tomography, Emission-Computed, Single-Photon / methods* Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Catecholamines; 0/Fibrin Fibrinogen Degradation Products; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/Troponin T; 0/fibrin fragment D; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2008 Apr;29(8):1072; author reply 1072-3
[PMID:
18308690
]
Eur Heart J. 2008 Mar;29(5):681; author reply 681-2 [PMID: 18238929 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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