Document Detail

The pathophysiologic role of myocardial depressant factor as a mediator of circulatory shock.
MedLine Citation:
PMID:  6181287     Owner:  NLM     Status:  MEDLINE    
Myocardial Depressant Factor (MDF) is a small peptide circulating in the blood of all mammalian species tested in a variety of shock states including endotoxic, hemorrhagic, cardiogenic, bowel ischemic, acute pancreatitis, burn, and traumatic shock. MDF is produced by the action of proteolytic enzymes released by the ischemic pancreas. MDF acts to depress myocardial contractility, constrict the splanchnic arteries and impair reticuloendothelial system phagocytosis. Several pharmacologic agents prevent the formation of MDF including membrane stabilizers (e.g., glucocorticoids), protease inhibitors (e.g., aprotinin), converting enzyme inhibitors (e.g., captopril), prostaglandins (e.g., PGE1 and PGI2), thromboxane synthetase inhibitors (e.g., imidazole, PTA2) and local anesthetics (e.g., lidocaine). Prevention of MDF formation or action improves survival. Thus, MDF is an important mediator of shock pathophysiology and should be considered in the therapy of circulatory shock states.
A M Lefer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  60     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  713-6     Citation Subset:  IM    
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MeSH Terms
Aprotinin / pharmacology
Cardiotonic Agents / pharmacology
Epoprostenol / pharmacology
Glucocorticoids / pharmacology
Mononuclear Phagocyte System / physiology
Myocardial Contraction
Myocardial Depressant Factor / antagonists & inhibitors,  biosynthesis,  physiology*
Pancreas / metabolism
Peptides / physiology*
Shock / physiopathology*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Glucocorticoids; 0/Myocardial Depressant Factor; 0/Peptides; 35121-78-9/Epoprostenol; 9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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