| The pathology of the heart conduction system in congenital heart block. | |
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MedLine Citation:
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PMID: 17029919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of congenital complete heart block is estimated in 1 of 2500-20,000 births. Many cases are isolated (found in an otherwise normal heart) and the pathology of the heart conduction system is variable. We report a 51-year-old man with the diagnosis of complete heart block, with a permanent pacemaker. No family history of rhythm disturbances was available. The patient presented and endocarditis after replacement of the pacemaker battery. The prognosis was poor and the patient died three months later. Autopsy examination showed signs of shock, of septic origin. The heart was hypertrophic (450g) and the left ventricle thickened. Histopathological examination of the heart conduction system showed that the sinus and atrioventricular nodes were normal, but the His bundle was interrupted and replaced by fibrous tissue. No inflammatory signs were present. Loss of conducting fibres and their replacement by fibrous tissue is the most common pathological process in complete heart block. In this case His bundle was mostly affected, different to Lev's disease where the process is more distal (branching atrioventricular bundle) and to Lenegre's disease, which shows a diffuse damage in the conducting system. |
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Authors:
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J M Suárez-Peñaranda; J I Muñoz; M S Rodríguez-Calvo; J A Ortíz-Rey; L Concheiro |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-10-06 |
Journal Detail:
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Title: Journal of clinical forensic medicine Volume: 13 ISSN: 1353-1131 ISO Abbreviation: J Clin Forensic Med Publication Date: 2006 Aug-Nov |
Date Detail:
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Created Date: 2006-10-23 Completed Date: 2007-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434927 Medline TA: J Clin Forensic Med Country: Scotland |
Other Details:
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Languages: eng Pagination: 341-3 Citation Subset: IM |
Affiliation:
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Department of Pathology and Forensic Sciences, University of Santiago de Compostela, Hospital Clínico, Travesía de Choupana s/n, 15702 Santiago de Compostela, Spain. jsuarezp@usc.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Bundle of His / pathology* Diagnosis, Differential Forensic Medicine Heart Block / congenital, pathology* Heart Conduction System / pathology Humans Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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