| The pathology of breast cancer and the role of the histopathology laboratory. | |
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MedLine Citation:
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PMID: 15997917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histopathology plays an important part in determining the treatment strategy for women with breast cancer, with the evaluation of breast specimens determining the surgical and the oncological therapeutic options used. The correct approach to specimens requires integration of clinical and imaging findings. This work is not trivial. It is time-consuming and skilled, and requires (and has in place) safeguards and checks in the form of national audit and quality-control schemes. The pathobiology of breast cancer is diverse, and the current taxonomy, rooted in morphological interpretation, has been underscored by molecular observations, such as the relationship of E-cadherin mutations to lobular carcinomas. Investigation of ductal carcinoma of no special type (NST) reveals covert tumour types, such as those with basal or myoepithelial features, whose distinctive features are only now being widely recognised. With the rise of modern molecular techniques, the demise of diagnostic histopathology has been predicted, but, for now and the intermediate future, the histopathologist remains a key element of the integrated breast-care team. |
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Authors:
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A M Hanby |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical oncology (Royal College of Radiologists (Great Britain)) Volume: 17 ISSN: 0936-6555 ISO Abbreviation: Clin Oncol (R Coll Radiol) Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-06 Completed Date: 2005-09-20 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9002902 Medline TA: Clin Oncol (R Coll Radiol) Country: England |
Other Details:
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Languages: eng Pagination: 234-9 Citation Subset: IM |
Affiliation:
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Academic Unit of Pathology, Leeds University. andrew.hanby@ntlworld.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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genetics,
pathology* Cadherins / genetics Carcinoma, Intraductal, Noninfiltrating / genetics, pathology* Carcinoma, Lobular / genetics, pathology* Diagnosis, Differential Female Humans Neoplasm Invasiveness* Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Cadherins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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