| The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease. | |
| | |
MedLine Citation:
|
PMID: 21042922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. METHODS: First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. RESULTS: There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = -1.359 + 0.143 × VFA + 0.046 × triglyceride + 0.059 × LDL, R(2) = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05). CONCLUSIONS: These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD. |
| | |
Authors:
|
Yuichiro Eguchi; Toshihiko Mizuta; Yoshio Sumida; Eriko Ishibashi; Yoichiro Kitajima; Hiroshi Isoda; Hiroko Horie; Takaya Tashiro; Eri Iwamoto; Hirokazu Takahashi; Takuya Kuwashiro; Shu Soejima; Yasunori Kawaguchi; Yasutomo Oda; Sei Emura; Ryuichi Iwakiri; Iwata Ozaki; Takahisa Eguchi; Naofumi Ono; Keizo Anzai; Kazuma Fujimoto; Shunzo Koizumi |
Publication Detail:
|
Type: Journal Article Date: 2010-11-02 |
Journal Detail:
|
Title: Journal of gastroenterology Volume: 46 Suppl 1 ISSN: 1435-5922 ISO Abbreviation: J. Gastroenterol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-11-29 Completed Date: 2011-03-15 Revised Date: 2011-05-13 |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
|
Languages: eng Pagination: 70-8 Citation Subset: IM |
Affiliation:
|
Department of General Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. eguchiyu@cc.saga-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Alanine Transaminase / blood Cholesterol, LDL / blood Disease Progression Electric Impedance Fatty Liver / pathology* Female Humans Inflammation / pathology* Intra-Abdominal Fat / pathology* Male Middle Aged Prognosis Regression Analysis Retrospective Studies Tomography, X-Ray Computed Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, LDL; 0/Triglycerides; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
Comment In:
|
J Gastroenterol. 2011 Mar;46(3):418; author reply 419-20
[PMID:
21222004
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Marking live conifer pollen for long-distance dispersal experiments.
Next Document: Evaluation of risk factors for the development of cirrhosis in autoimmune hepatitis: Japanese NHO-AI...