Document Detail

The pathognomonic cytologic picture of rheumatoid pleuritis. The 1989 Maurice Goldblatt Cytology award lecture.
MedLine Citation:
PMID:  2197838     Owner:  NLM     Status:  MEDLINE    
Patients with rheumatoid arthritis of any degree of severity or duration may develop necrotizing granulomatous pleuritis, a morphologic replica of the inflammatory reaction characteristic of rheumatoid synovitis and rheumatoid nodules. The ensuing pleural effusion may show a unique cytologic picture consisting of slender, elongated multinucleated macrophages, round giant multinucleated macrophages and necrotic background material. A review of 24 such cases from our laboratory as well as the relevant literature clearly demonstrated that not only is this cytologic picture unique, but that it is pathognomonic of rheumatoid disease, even in patients who have not yet developed arthritis.
B Naylor
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta cytologica     Volume:  34     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1990-08-28     Completed Date:  1990-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-73     Citation Subset:  IM    
Department of Pathology, University of Michigan, Ann Arbor.
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MeSH Terms
Arthritis, Rheumatoid / pathology*,  physiopathology
Connective Tissue / pathology
Pleural Effusion / pathology
Pleurisy / etiology,  pathology*

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